A Cytogenetic Study and Search for Suspected Fragile X Chromosomes in Selected Individuals from the Chaldean Population in Detroit
Abstract
Many Chaldean families exhibit a high incidence of X-linked
mental retardation. One possible explanation for ·this
phenomenon is the presence of an inherited fragile X chromosome.
A cytogenetic analysis of peripheral blood lymphocytes
from several individuals from Chaldean families was performed.
Fragile~X chromosomes were found in three individuals; however,
the heritability was not established. A possible new fragile
site on chromosome 2 was seen in several individuals, but
again, heritability was not shown. One family was found in
which a high amount of breakage in certain cells was observed.