Interactions of the B16F10 Murine Melanoma with Human Anmiotic Basement Membrane
Clark, Judith M.
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Metastasis is the complex multistep process by which malignant tumor cells spread from the primary tumor to form secondary tumors (metastases) at distant sites in the body. With regard to patients with clinical cancer, most therapeutic failures occur because patients succumb to these secondary growths. Of prime importance in the metastatic process is the phenomenon of invasion. By penetrating normal host tissue barriers, malignant cells enter the circulation and may be able to form metastases at secondary sites. Human amniotic basement membrane, one such tissue barrier, is similar in structure to tissue barriers found in other parts of the body (i.e. lining blood vessels). The present study focuses on the interactions of the Bl6F10 murine melanoma (a highly malignant cell line) with human amniotic basement membrane.