The Dynamics of Anti-Lymphocyte Activity in Horses Hyperimmunized with Human Thymus Tissue
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Authors
Zotovas, Andrea
Issue Date
1985
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Horse plasma was obtained at 30-day timed intervals from horses which were hyperimmunized with human thymocytes. Rosette Inhibition Titer assay of total immunoglobulin fractions from these samples indicated that the anti-thymocyte activity remained relatively constantly after initial increase at 30 days. Lymphoagglutination assay of the same samples indicated an increase in anti-thymocyte activity after 90 days, while lymphocytotoxicity decreased after 90 days. Purified lgT and IgG subfractions from three of these five samples were also assayed. Rosette Inhibition Titer, Lymphoagglutination and lymphocytotoxicity assay of the purified IgT and IgG subfractions did not indicate that a disproportionate amount of the anti-thymocyte activity of this hyperimmune equine immunoglobulin resides in IgT.
Description
37 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.