Penetration, Mode of Action, and Metabolism of C14-Labelled Banamite in Boll Weevils
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Authors
Stauffer, Susan
Issue Date
1972
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Radiolabelled benzoyl chloride (2,4,6-trichlorophenyl)
hydrazone was topically applied to boll weevils.
A time study was made to investigate the rate of penetration,
the mode of action g and the metabolism of the compound
within the insect. At an approximate dosage of
0.5µg, 75% of the compound will penetrate the insect within
24 hours. The original compound, benzoic acid, -2(2,4,6-
trichlorophenyl) hydrazide, and 2,4,6-trichloroaniline,
all containing C14 , were detected within the insect and
the latter two are probably metabolic products of the
first. Tracing the location of the highest concentrations
of radioactivity indicates that following penetration
the compound is in a benzene-soluble state, it enters a
water-soluble state, then settles in the solid integumentary
structures of the insect. Radioactivity was also found
in the feces and in volatile respiratory products. The
mode of action considered here involves noncompetitive
complexing of the Banamite with an essential enzyme.
This consideration deserves further study.
Description
iii, 32 p.
Citation
Publisher
Kalamazoo College
License
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