The Short-Term Effect of Cocaine upon Acutely Depressed Patients
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Cocaine administered orally to patients suffering from manic-depressive illness does not appear to have antidepressant effects over the given dosage range. Since gastrointestinal absorption of the drug may be poor, significant blood levels may not have been obtained, although the effect on REM sleep suggest cocaine was physiologically active. Cocaine administered intravenously often resulted in an initial positive subjective change, but . was followed by significant expression of emotion including tears (corresponding with the peak vital sign changes) that could not be viewed simply as mood elevation. Statistical analysis of this preliminary work with eleven patients is out of the question. Hopefully the work will be continued upon a more significant number of patients with possibly larger doses of cocaine used until less equivocal results are obtained.