Ouabain Binding to Rabbit Erythrocytes
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Authors
Peck, Bruce F., II
Issue Date
1972
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Ouabain is a digitalizating cardiac glycoside. Digitalis is a drug that is administered to patients with congestive heart failure. The net effect of these cardiac glycosides
are (1) a more complete systolic emptying decreasing the
over all heart size, (2) a reduction in the venous blood
pressure and (3) a decreasing in the rate of heart contractions.
Cardiac glycosides however can build up to toxic levels in
these hearts patients. Currently' there are no tests to measure
cardiac glycoside build up. Cardiac glycosides not only
complex or bind t.o myocardial tissue but they also complex
with erythrocyte membranes. Ideally, if a relationship
between ouabain binding to erythrocyte membrane and binding to
heart membranes could be established an optimal dosage, of the
drug could be determined for each heart patient through a
simple blood test.
The relation between ouabain binding to heart membranes
and erythrocyte membranes was begun on human erythrocytes.
Because of the impracticability of research on human heart
membranes, rabbits were used. Since the basic work of ouabain
binding had been done on human erythrocytes and ouabain
binding to heart membranes was to be done on rabbits, a study
on the effect of ouabain binding had to be done on rabbit
erythrocytes.
The results of this study point out many inconsistances
between the human ouabain binding system and the rabbit.
Comparisons between the results of the rabbit research can
not be applied to humans.
Description
iii, 29 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.