The Effects of Picolinaldehyde 5-Hydroxy Thiosemicarbazone on the Cell Cycle of Cultured Mammalian Cells
Zoerhof, William N.
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Underlying the conce9ts to be presented in this paper is the basic idea of cell cycle. The cell cycle is defined as the interval between the completion of mitosis in a cell and completion of mitosis in one or both daughter cells. The cell cycle is divided into G1, the interval between completion of mitosis and the onset of DNA synthesis; S, the period during which DNA replicates; G2, the period between completion of DNA synthesis and the onset of mitosis; and lastly mitosis in its four stages from prophase to telophase. The four phases of the cell cycle owe their individuality to the biochemical events which take place during each of them. These reactions can be altered or even stopped through the introduction of certain chemicals to the system.