The Effect of Aspirin on the Blood Platelet Release Reaction
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Authors
Walker, Richard
Issue Date
1971
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Blood platelets as a part of their participation in the clotting release certain intracellular
constituents in response to thrombin and other clot
promoting substances. This is commonly called the
"release reaction". Acetyl salycilic acid (ASA) is known to
inhibit the release reaction as are certain other anti-inflammatory
drugs, though the mechanism through which
ASA effects inhibition is not known. This question was therefore
of some interest and these experiments attempt to show
how ASA might work to inhibit release. This question is in
itself quite important and other related question such as how
release itself occurs might be in part answered if it is known
how it is inhibited. The platelet membrane is implicated in
this role but its exact function has not been determined.
Description
22 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.