The Effect of Aspirin on the Blood Platelet Release Reaction
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Blood platelets as a part of their participation in the clotting release certain intracellular constituents in response to thrombin and other clot promoting substances. This is commonly called the "release reaction". Acetyl salycilic acid (ASA) is known to inhibit the release reaction as are certain other anti-inflammatory drugs, though the mechanism through which ASA effects inhibition is not known. This question was therefore of some interest and these experiments attempt to show how ASA might work to inhibit release. This question is in itself quite important and other related question such as how release itself occurs might be in part answered if it is known how it is inhibited. The platelet membrane is implicated in this role but its exact function has not been determined.