|dc.contributor.author||Simpson, Rosetta Loree||
|dc.description||iii, 44 p.||en_US
|dc.description.abstract||This paper is first addressed to delayed hypersensitivity
in vitro using rabbit alveolar macrophages, wh1ch
belong to a group characterized by a relatively high mitotic rate and the ability to attack and spread readily on
glass, rather than peritoneal macrophages of guinea pigs.
Several experiments were initiated with rabbit lymphocytes
and human peripheral leucocytes to determine the techniques
involved in the cell migration of lymphocytes and peripheral
Also, tissue cultures of alveolar macrophages were
set up to observe the motility of the cells and to extend
the life span of macrophages after having been collected
from the lungs.
Secondly, this paper describes the function of rabbit
alveolar macrophages in rosette formation and rosette inhibition.
It is known that human lymphocytes react through
an immunospecific mechanism with Sheep Red Blood Cells (SRBC)
causing 5 or 6 SRBC to adhere to lymphocytes, forming a
rosette. The lymphocytes have receptors that recognize the
antigen (SRBC). Rosette-inhibition means that the inhibitor
coats the lymphocyte, thus inactivating it by covering their
receptors which cannot pick up SRBC. It was of theoretical
and practical interest to determine whether or not rabbit.
alveolar macrophages formed rosettes in the SRBC system.
The report describes further rosette formation and rosette
inhibition with human lymphocytes and rabbit lymphocytes.||en_US
|dc.description.sponsorship||Upjohn Company. Kalamazoo, Michigan.||
|dc.relation.ispartof||Kalamazoo College Biology Senior Individualized Projects Collection||
|dc.relation.ispartofseries||Senior Individualized Projects. Biology;||
|dc.rights||U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.||
|dc.title||Selected Aspects of Macrophage Biology||en_US
|KCollege.Access.Contact||If you are not a current Kalamazoo College student, faculty, or staff member, email email@example.com to request access to this thesis.||