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dc.contributor.advisorMorrell, Roger
dc.contributor.authorSimpson, Rosetta Loree
dc.descriptioniii, 44 p.en_US
dc.description.abstractThis paper is first addressed to delayed hypersensitivity in vitro using rabbit alveolar macrophages, wh1ch belong to a group characterized by a relatively high mitotic rate and the ability to attack and spread readily on glass, rather than peritoneal macrophages of guinea pigs. Several experiments were initiated with rabbit lymphocytes and human peripheral leucocytes to determine the techniques involved in the cell migration of lymphocytes and peripheral leucocytes. Also, tissue cultures of alveolar macrophages were set up to observe the motility of the cells and to extend the life span of macrophages after having been collected from the lungs. Secondly, this paper describes the function of rabbit alveolar macrophages in rosette formation and rosette inhibition. It is known that human lymphocytes react through an immunospecific mechanism with Sheep Red Blood Cells (SRBC) causing 5 or 6 SRBC to adhere to lymphocytes, forming a rosette. The lymphocytes have receptors that recognize the antigen (SRBC). Rosette-inhibition means that the inhibitor coats the lymphocyte, thus inactivating it by covering their receptors which cannot pick up SRBC. It was of theoretical and practical interest to determine whether or not rabbit. alveolar macrophages formed rosettes in the SRBC system. The report describes further rosette formation and rosette inhibition with human lymphocytes and rabbit lymphocytes.en_US
dc.description.sponsorshipUpjohn Company. Kalamazoo, Michigan.
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleSelected Aspects of Macrophage Biologyen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

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  • Biology Senior Individualized Projects [1489]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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