Hydrolysis of Ara-C Esters in Mouse and Human Body Fluids
Abstract
Enzymatic hydrolysis rates for 21 ara-C esters were determined
using the Streptococcus faecalis assay for ara-C. Rates obtained
in the two human fluids studied -- plasma and synovial fluid - correlated
well. Mouse plasma results correlated with these two
to a lesser extent. Attempts to relate these rates to in vitro
nonenzymatic hydrolysis data and in vivo biological activity failed
to produce any strong correlations.