Artificially Induced Handedness as a Possble Mechanism of Compensation for Deficiencies of Genu-Lesioned Rhesus Monkeys in Learning Spatial Delayed Alternation
Campbell, David G.
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Rhesus macaques were given lesions of the genu and taught spatial delayed alternation tasks. They were then tested for handedness and given unilateral dorsolateral frontal lesions both ipsilateral and contralateral to the preferred hand. Control monkeys were given the same tests and frontal lesions but were not given lesions of the genu. The monkey given the contralateral frontal lesion in the genu group failed to retain spatial delayed alternation, of the two given ipsilateral lesions, one failed and one passed. Artificially induced interhemispheric dominance did not appear to be a factor in the recovery of Rhesus of the ability to learn spatial delayed alternation after lesion of the genu. The results suggest that something other than simple prefrontal - prefontal connections are disrupted by lesions of the genu; perhaps prefrontal-premotor connections as well.