The Effects of 3-Chloro-1,2-Propanediol on Freshwater Populations of Euglena Gracilis
Sadewasser, Steven G.
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On November 4, 1969, Dr. Ronald J. Ericsson of The Upjohn Company in Kalamazoo presented a seminar at Kalamazoo College entitled, "Male Anti-fertility." During his presentation, he discussed a drug that has been tested particularly in the area of prevention of spermatazoa maturation. This drug, 3-chloro-1,2-propanediol which is known at Upjohn as Agent U-5897,was found to be particularly effective. U-5897, a chlorohydrin, is known to markedly decrease the capability of lab animals to produce fertile sperm. The study presented here will be concerned with the proposed distribution of the drug. In personal communication with Ericsson, it was noted that the drug would probably be used in a bait form around refuse areas of tenement buildings in cities. Due to the low price of the drug, it could be released over large areas of the country in a relatively inexpensive program. Since the drug is a water soluble chlorohydrin, however, several problems develop. One major problem, the one considered here, is the effect that this drug will have on freshwater environments. Since 3-chloro-I,2-propanediol is water soluble, it could be introduced to a lake, stream, or water supply either by accident or by large run offs from baits. The study here concerns the effects of the drug on one freshwater species, Euglena gracilis.