A Morphological and Histological Investigation into the Reproductive Anatomy of C57BL/6J - X/Y^h Hermaphroditic Mice
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External and internal reproductive anatomy was examined in 307 C57BL/6J mice carrying a Y-linked mutation known to produce true hermaphroditism. Histological preparations were made from gonads of a representative sample of 64 hermaphrodites, which expressed a wide range of variation in their internal reproductive organs. Analysis revealed that 98% of these gonads were ovotestes and 2% were ovaries; no testes without ovarian tissue were found. In addition, a direct correlation was found between ovotestis development and the phenotypic development of the reproductive anatomy. A preliminary investigation of gonads from 15 day old C57BL/6J fetuses carrying this mutation was done to ascertain the early development of the hermaphroditic gonad. Results are discussed in terms of their implications for genetic mechanisms of sex differentiation.