Embryonic Cell Aggregate Shape Changes During Parallel Plate Compression
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Morphogenetic embryonic tissue interactions can be studied in vitro. It has been found through in vitro studies that embryonic tissue cells adhere preferentially to like cells, and further, that a specific hierarchy exists for adhesion between unlike cells. It has been suggested that this differential adhesion is responsible for morphogenetic tissue movements. Centrifugation studies conducted on embryonic chick cell aggregates have indicated that each tissue may act as an elasticoviscous liquid within the developing system. In other words, cells within a tissue may at first stretch when distorted, but then the cells within the tissue will change their relative positions, and cell shapes will return to normal. However, the electicoviscous liquid model of tissue movements has lacked verification by experimental methods other than centrifugation. This study attempted to determine if dissociated chick embryonic tissue that has been reaggregated behaves according to the elasticviscous liquid model of tissue flow when compressed between two parallel plates. Unfortunately, a combination of factors prevented the above hypothesis from being definitely tested.