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dc.contributor.advisorMcGovren, J. Patrick
dc.contributor.authorSem, Philip Chan Chee
dc.descriptionvi, 36 p.en_US
dc.description.abstractAT-l25, an antitumor agent, was isolated from soil microorganism, streptomyces sviceus UC-5370, and was found to be active against P388 and L12l0 mouse leukemias, and against human breast and lung tumors transplanted into 'nude' mice. It was found that AT-125 was more toxic to female mice than male mice of both ICR end BDFl strains (Neil et aI, 1978). McGovren (1978a.) showed that female ICR mice had a slower AT-l25 plasma clearance rate than male mice. The objectives of this project were to investigate the plasma clearance of AT-l25 by male and female mice of the BDFl and CDFI mouse strains, to study the extent of urinary excretion of AT-l25 in ICR male and female mice and to perform a preliminary search for metabolites of AT-125 in mouse urine by means of bioautography. The results obtained were: (I) In BDFI and CDFI mouse strains, female mice were also slower in AT-125 clearance rates than males. Only small differences were seen in clearance between BDFl, CDFI and ICR strains. (2) Most of the injected dose of AT-l25 was recovered in the urine over 24 hours in both sexes of ICR mice and the t-test conducted on the urine data showed that there was no sex difference in the excretion of AT-125. (3) The results of the third study suggested that the urine of AT-125 treated ICR mice (both male and female) contained only unchanged AT-125 and no active metabolites.en_US
dc.description.sponsorshipUpjohn Company. Kalamazoo, Michigan.
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleSex-related Differences in the Disposition of the Potential Antitumor Drug, AT-125, in Miceen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

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  • Biology Senior Individualized Projects [1489]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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