|dc.contributor.advisor||McGovren, J. Patrick||
|dc.contributor.author||Sem, Philip Chan Chee||
|dc.description||vi, 36 p.||en_US
|dc.description.abstract||AT-l25, an antitumor agent, was isolated from soil
microorganism, streptomyces sviceus UC-5370, and was found
to be active against P388 and L12l0 mouse leukemias, and
against human breast and lung tumors transplanted into 'nude'
mice. It was found that AT-125 was more toxic to female mice
than male mice of both ICR end BDFl strains (Neil et aI, 1978).
McGovren (1978a.) showed that female ICR mice had a slower AT-l25
plasma clearance rate than male mice. The objectives of this
project were to investigate the plasma clearance of AT-l25
by male and female mice of the BDFl and CDFI mouse strains,
to study the extent of urinary excretion of AT-l25 in ICR male
and female mice and to perform a preliminary search for metabolites
of AT-125 in mouse urine by means of bioautography.
The results obtained were: (I) In BDFI and CDFI mouse strains,
female mice were also slower in AT-125 clearance rates than males.
Only small differences were seen in clearance between BDFl, CDFI
and ICR strains. (2) Most of the injected dose of AT-l25 was
recovered in the urine over 24 hours in both sexes of ICR mice
and the t-test conducted on the urine data showed that there was
no sex difference in the excretion of AT-125. (3) The results
of the third study suggested that the urine of AT-125 treated
ICR mice (both male and female) contained only unchanged AT-125
and no active metabolites.||en_US
|dc.description.sponsorship||Upjohn Company. Kalamazoo, Michigan.||
|dc.relation.ispartof||Kalamazoo College Biology Senior Individualized Projects Collection||
|dc.relation.ispartofseries||Senior Individualized Projects. Biology;||
|dc.rights||U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.||
|dc.title||Sex-related Differences in the Disposition of the Potential Antitumor Drug, AT-125, in Mice||en_US
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