The Effect of Exercise and Epinephrine on Platelet Aggregation
MetadataShow full item record
Platelets can be aggregated in vitro by the use of a variety of substances such as collagen, ADP, thromboxane A2, and epinephrine. Moderate exercise, a form of stress, is known to increase plasma catecholamine levels. It has been suggested that the increased plasma epinephrine levels enhance platelet-platelet interaction. Platelet thrombi may form from this interaction and proceed to occlude various blood vessels, including the myocardium and cerebrum with serious consequences. The present study was designed to determine the effect of epinephrine produced by exercise on platelet aggregation as well as the effect of administered epinephrine on platelet aggregation. Although plasma catecholamines increased significantly after both events and the platelet count also increased significantly, the in vitro aggregation of platelet rich plasma by ADP and collagen showed a decrease in the extent of platelet aggregation.