Measurement of Uterine Contractility in the Rhesus Monkey by Radio Telemetry
Glenn, Thomas C.
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This present study investigates a new, unique, in vivo technique for measuring uterine contractile pressure in the female rhesus monkey ( Macaca mullata ). The new method involves the implantation of a radio telemeter into the musculature of the monkey's uterus. The telemeter had two tasks. First, the telemeter was used to characterize the contractile activity during the menstrual cycle. Secondly, several compounds were administered to the test animal and monitored by the telemeter to study their effects upon uterine motility. Two prostaglandin compounds ( PGE2 -and PGF2 ) were studied for their contractile promoting activity. Relaxin and Indomethacin were also monitored for their inhibiting properties on smooth muscle activity.