Relationships Between the Quantity of Lipid Transfer Complex and the Levels of Plasma Lipoproteins in Humans
Powley, Scott G.
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A glycoprotein complex that facilitates the transfer of cholesteryl esters (CE) and tryglycerides (Tg) between the different classes of lipoproteins has been isolated from human and laboratory animal blood plasma by ultracentrifugation at d = 1.21 gm/ml and gel filtration chromatography. The method of in vitro assay with radio labeled CE determined the activity; and Laurell immunoelectrophoresis determined the relative mass of LTC present in 29 different human plasma samples. The mass and activity were positively correlated with the low density lipoprotein (LDL)-cholesterol level and inversely correlated with the fraction of the total cholesterol found in the high density lipoprotein (HDL) fraction. These results are paralleled by studies conducted with rats and rabbits and suggest that the LTC plays a role in regulating the plasma lipid concentrations.