Use of a Surface Balance in Assessing Phospholipase A2 Inhibitors: A Feasibility Study
Glaum, Steven Richard
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The primary goal of our research was to establish the feasibility of the nonolayer technique for following inhibition of membrane-bound enzymatic reactions. It was our intention to develop a method to quickly screen potential drug candidates in a reproducible manner. Additionally, our monolayer technique was designed to complement and confirm the results of existing bulk solution studies. Because the method affords the investigator the parameter of a variable hydrophobic interface, it provides additional information as to the nature of the reaction in vivo.