Effects of Iron Deficiency on the Expression and Function of Transferrin Receptors in K562 Leukemia Cells
Cudkowicz, Alexander R.
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The effects of iron deficiency on the expression and function of transferrin receptors was studied in K562 human leukemia cells. It was found that cells respond immediately by speeding up the transferrin cycle i.e. the rate at which saturated transferrin is internalized, the iron removed, and the apo-Tf released. They respond, in this way to iron deficiencies both outside and within the cell. When grown for periods over 24 hours in iron deficient environments, cells developed additional receptors for transferrin. This response, however, was affected only by a deficiency within the cell.