The Effects of Antibiotics on Leukocyte Chemotaxis
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Authors
Talley, Carol
Issue Date
1978
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Twenty three antibiotics, possessing a wide variety of biochemical
modes of action, were surveyed for their effects on human
leukocyte chemotaxis in vitro. Chemotaxis was measured using a
synthetic tripeptide and filtrates from cultures of E. coli and
P. granulosum. Most of the antibiotics had no specific inhibitory
effects. However, consistent chemotactic inhibition was seen
with those antibiotics whose antibacterial mode of action is
inhibition of RNA synthesis. These included: tirandamycin, rifamycin
B, streptolydigin, streptovaricin, and rifampicin. The
inhibitory effect of one antibiotic, rifampicin, was found to be
a function of the concentration of the chemotactic agent; that
is, high concentrations of rifampicin, which were inhibitory at
low chemotactic agent concentrations, not only were no longer
inhibitory, but they appeared to actually reverse the deactivation
of chemotaxis caused by excessively high. concentrations
of chemotactic agents.
Description
v, 46 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.