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dc.contributor.advisorSproul, Mryna G.
dc.contributor.advisorLobl, Thomas J.
dc.contributor.authorScicluna, Mary T.
dc.descriptioniv, 55 p.en_US
dc.description.abstractMale rats were administered either a progestin, an estrogen, or an estrogen antagonist, alone, and in combination with androgen. The effects on spermatogenesis were observed. In addition, serum FSH, LH, and testosterone were measured by the method of double antibody radioimmunoassay. The effect of the drugs on Androgen Binding Protein (ABP) levels in the serum, the testis and the epididymis was the major consideration. Androgen Binding Protein is a product of the Sertoli cell of the testis and has been shown to be important in the transport of sperm and androgen from the testis to the epididymis and in spermatid maturation. This experiment was designed to determine if ABP plays a role in the regulation of the spermatogenic process. While conclusive evidence has not been found which supports this possibility, several experimental findings indicate that it is feasible.en_US
dc.description.sponsorshipUpjohn Company
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleThe Effect of a Progestin, an Estrogen and an Estrogen-Antagonist on Androgen Binding Protein Levels in the Intact Male Raten_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

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  • Biology Senior Individualized Projects [1520]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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