Pharmacodynamics of Intravenously Administered Phospholipid
Verbanac, Kathryn M.
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Lecithin is the only agent that has been shown to reverse experimental atherosclerosis in more than one animal species, when administered intravenously. Although the mechanism of phospholipid action has not been established, it is thought that phospholipid would presumably be increased if the in vivo decay curve was extended. This study investigated various means to retard phospholipid removal from plasma of Japanese quail. The physical state of the phospholipid was manipulated with special attention paid to particle and size and change. These manipulations included the use of ultrasonic radiation and surface-active agents. Results revealed cholesterol mobilization in plasma of animals injected with the phospholipid. Small phospholipid vesicles were retained longer in the bloodstream than were large ones. Negatively charged particles were cleard faster than neutrally charged phospholipid.