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dc.contributor.advisorKafka, Marian
dc.contributor.advisorSproul, Mryna G.
dc.contributor.authorDuncan, Phillip J.
dc.descriptionv, 38 p.en_US
dc.description.abstractProstaglandin El , E2 , Fl and. F2 stimulation of adenylate cyclase to produce cyclic Ar~lP was studied in human. blood platelets. L-norepinephrine, an alpha adrenergic agonist in platelets, inhibits the production of cyclic AMP stimulated by PGE1 by increasing the apparent Km of PGE1. This seems to indicate that the I-norepinephrine is decreasing the affinity PGEl has for stimulating adenylate cyclase. Investigations in the mode of action of prostaglandin stimulation of adenylate cyclase revealed a membrane bound receptor site for PGE1 - Binding studies supported by cAMP assays showed that PGE1 and PGE2 may share a co~~on receptor site while ,there may exist a separate PGF receptor site. L-norepinephrine was shown not to affect binding of PGE1, which provides evidence that the inhibition of the alpha-adrenergic agonist may be . directly on the adenylate cyclase system.en_US
dc.description.sponsorshipNational Institutes of Health
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleProstaglandin E1 Receptor Binding in Human Blood Platelets Stimulation and Inhibition of Adenylate Cyclaseen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

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  • Biology Senior Individualized Projects [1489]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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