JavaScript is disabled for your browser. Some features of this site may not work without it.
  • About K
  • Academics
  • Admission
  • Alumni Relations
  • Giving to K
  • News & Events
  • Student Life
  • HORNET HIVE
  • ATHLETICS
  • SITEMAP
  • WEBMAIL
    • Login
    View Item 
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Biology
    • Biology Senior Individualized Projects
    • View Item
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Biology
    • Biology Senior Individualized Projects
    • View Item

    Prostaglandin E1 Receptor Binding in Human Blood Platelets Stimulation and Inhibition of Adenylate Cyclase

    Thumbnail
    View/Open
    Searchable PDF / Kalamazoo College Only (1.775Mb)
    Date
    1977
    Author
    Duncan, Phillip J.
    Metadata
    Show full item record
    Abstract
    Prostaglandin El , E2 , Fl and. F2 stimulation of adenylate cyclase to produce cyclic Ar~lP was studied in human. blood platelets. L-norepinephrine, an alpha adrenergic agonist in platelets, inhibits the production of cyclic AMP stimulated by PGE1 by increasing the apparent Km of PGE1. This seems to indicate that the I-norepinephrine is decreasing the affinity PGEl has for stimulating adenylate cyclase. Investigations in the mode of action of prostaglandin stimulation of adenylate cyclase revealed a membrane bound receptor site for PGE1 - Binding studies supported by cAMP assays showed that PGE1 and PGE2 may share a co~~on receptor site while ,there may exist a separate PGF receptor site. L-norepinephrine was shown not to affect binding of PGE1, which provides evidence that the inhibition of the alpha-adrenergic agonist may be . directly on the adenylate cyclase system.
    URI
    http://hdl.handle.net/10920/22441
    Collections
    • Biology Senior Individualized Projects [1550]

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    DSpace software copyright © 2002-2021  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV
    Logo

    Kalamazoo College
    1200 Academy Street
    Kalamazoo Michigan 49006-3295
    USA
    Info 269-337-7000
    Admission 1-800-253-3602

    About K
    Academics
    Admission
    Alumni Relations
    Giving to K
    News & Events
    Student Life
    Sitemap
    Map & Directions
    Contacts
    Directories
    Nondiscrimination Policy
    Consumer Information
    Official disclaimer
    Search this site


    Academic Calendars
    Apply
    Bookstore
    Crisis Response
    Employment
    Library
    Registrar
    DSpace Express is a service operated by 
    Atmire NV