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dc.contributor.advisorKaiser, David G.
dc.contributor.authorMagneson, Gerald R.
dc.descriptionv, 29 p.en_US
dc.description.abstractResults from studies in dogs showed that, after single-dose oral administration, the (-) isomers of hydratropic acid, m-fluorohydratropic acid and p-fluorohydratropic acid were stereoselectively inverted to the (+) isomers. As compared to the ratio of (+) and (-) isomers from the intact drug in peripheral circulation or excreted in urine, the (+) isomers of hydratropic acid and m-fluorohydratr6pic acid were preferentially conjugated to glycine. Little, if any, isomeric inversion was found after oral administration of (-)-2- phenylbutyric acid. It is concluded that introduction of a fluorine atom into the positions meta or para to the aromatic nucleus of hydratropic acid does not inhibit stereoselective isomer inversion in dogs.en_US
dc.description.sponsorshipUpjohn Company
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleThe Stereoselective Metabolism of Some Fluorinated Hydratropic Acidsen_US

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  • Biology Senior Individualized Projects [1489]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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