Conditional Avoidance Response Studies in Mice
Fitzgerald, Laurence A.
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Discrete one-way conditioned avoidance response (CAR) in mice was employed in six related experiments. Experiment 1 explored foot-shock parameters affecting CAR acquisition in the undrugged state. Separation was most evident when both current and voltage were altered together. Experiment 2 shows a selective suppression of avoidance over escape with chlorpromazine, but only significant at a high shock intensity. Experiment 3 shows this selective suppression at both high and low shock intensities using pretrained subjects. Experiments 4 and 6 demonstrate transfer to the normal state for both chlorpromazine and morphine. Training by CAR acquisition proved more reproducible and gave higher performance during retest than training by preshock exposure with no escape. Experiment 5 shows selective suppression with morphine. Results are discussed comparing the CAR effects of different shock parameters, selective suppression of chlorpromazine and morphine, and transfer to the normal state.