Modulation by Prostaglandins of Cyclic AMP and Cyclip GMP Levels in Intact Viable Rat Lung Cells
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Cyclic AMP is believed to be a mediator in the anaphylactic reaction of asthma. High intracellular levels of cAMP will inhibit histamine release from cells. Because many asthmatics are insensitive to the . drugs now in use against asthma, an attempt was made to discover other agents that would raise cAMP levels in cells. Incubation of cells with prostaglandins E1 and F2a was studied to determine if these agents would effect the levels of cAMP and cGMP in rat lung cells. Basal levels of these cyclic nucleotides were also determined and were found to vary greatly from one cell pool to another. PGE1 increased levels of cAMP and had no effect on cGMP levels. PGF2a had no effect on levels of either cyclic nucleotide.