An Investigation on Serum Lipid Levels in Various Inbred Strains of Mice
Schmidt, Charline M.
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Ten inbred strains of mice were placed on several diets (Control, high-carbohydrate, and high-cholesterol) to observe the effects on Heparin Precipitated Lipoprotein (HPL) and serum cholesterol levels. The cholesterolaemic response to dietary cholesterol was verified by the different serum cholesterol values obtained from the groups, indicating the existence of inheritable factors (strain differences). The strain that produced the highest HPL and serum cholesterol value was the hypercholesterolaemic (HPC) male mice that were maintained on the high-fat diet. The high carbohydrate diet had very little effect on most of the strains; only Obese (OB) and HPC females responded well to that diet, showing increases in HPL and cholesterol levels. Most important of all, is that the combination of the HPC mouse and the high-fat diet causes the B-lipoproteins to obtain levels that are similar to those in man. On the basis of this knowledge, the HPC male would make a good experimental model for atherosclerosis.