The Isolation and Purificaiton of Alpha-Fetoprotein from Human Fetal Liver
Scott, Marjorie L.
MetadataShow full item record
The discovery of a genetic variant of AFP would be helpful in determining the true biosynthetic mechanism. This could help determine its structure as well as show which genes are responsible for the synthesis and localization at the organismal and cellular levels. A possible repressor could be determined if one does indeed exist. This investigation ties in mainly with the clinical value of AFP. The more that is known about AFP the more that will be able to be determined about its role in tumor diagnosis and therapy. It can also possibly be used as an indication of fetal well-being. In order to obtain knowledge about AFP, an isolated and pure product must be used whenever possible for various tests and structure determination. A simple and thorough isolation and purification process has been developed from a composite of the best techniques of previous attempts to isolate and purity this protein.