Renal Histological Study of the AYKK and the AYTKK Hybrids of Mice
Loading...
Authors
Perejda, Andrea Jeanne
Issue Date
1974
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
A renal age study from four through eight months of age was
performed on a new hybrid of mice, the AYKK mice, to see whether
or not they displayed any signs of diabetes. Kidneys from another
new hybrid, the AYTKK, were also examined at one, two, six and
fifteen months of age. Kidneys of these mice were fixed, sectioned
and stained with hematoxylin and eosin, allochrome, and sodium
sulfate Alcian Blue. Examination of the kidneys revealed no
diabetic nodular glomerulosclerosis, but all displayed severe
amyloidosis and hyalinization by eight months of age. Urine and
blood analysis of AYKK mice were also performed. No hyperglycemia,
glucosuria or ketonuria was found. They did display hyperinsulinemia
however, as well as proteinuria. Possible causes of amyloidosis
and proteinuria are discussed as well as their relationships to
one another.
Description
v, 33 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.