|dc.contributor.advisor||Olexia, Paul D., 1939-||
|dc.description.abstract||Urinary kallikrein is an enzyme which acts on an
-2 globulin called kininogen to produce kallidin (lysylbradykinin)
the decapeptide precursor of bradykinin. The
name bradykinin refers to the ability of the peptide to induce
slow contraction of guinea pig ileum in vitro. These kinin
peptides are among the most powerful vasodilators known.
The role of kallikrein and kinins in hypertension has not
been delineated, though it has been reported that the amount
of the nondialyzable, hypotensive substance (kallikrein)
in urine is reduced in patients with essential hypertension.
Subsequent work has demonstrated that urinary and renal
kallikrein are similar and differ from plasma kallikrein.
Although it has not been proven conclusively that urinary
kallikrein is formed in and secreted by the kidney, it has
been suggested that renin and kallikrein are located in the
same subcellular kidney fraction. Investigation of the
kallikrein-kinin system in human and experimental forms of
hypertension has been minimal. As a part of the investigation
of the kallikrein-kinin system in hypertensive disease, an
attempt was made to measure the amount of kallikrein in the
cortex of the kidney in spontaneously hypertensive, renal
hypertensive, and normotensive Sprague-Dawley rats. A bioassay
method was used to determine the various levels of bradykinin.
The data compiled was compared to similar studies measuring
|dc.relation.ispartof||Kalamazoo College Biology Senior Individualized Projects Collection||
|dc.relation.ispartofseries||Senior Individualized Projects. Biology;||
|dc.rights||U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.||
|dc.title||The Measurement of the Amount of Kallikrein in the Cortex of the Kidney of Spontaneously Hypertensive, Renal Hypertensive, and Normotensive Rats||en_US