The Measurement of the Amount of Kallikrein in the Cortex of the Kidney of Spontaneously Hypertensive, Renal Hypertensive, and Normotensive Rats
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Urinary kallikrein is an enzyme which acts on an -2 globulin called kininogen to produce kallidin (lysylbradykinin) the decapeptide precursor of bradykinin. The name bradykinin refers to the ability of the peptide to induce slow contraction of guinea pig ileum in vitro. These kinin peptides are among the most powerful vasodilators known. The role of kallikrein and kinins in hypertension has not been delineated, though it has been reported that the amount of the nondialyzable, hypotensive substance (kallikrein) in urine is reduced in patients with essential hypertension. Subsequent work has demonstrated that urinary and renal kallikrein are similar and differ from plasma kallikrein. Although it has not been proven conclusively that urinary kallikrein is formed in and secreted by the kidney, it has been suggested that renin and kallikrein are located in the same subcellular kidney fraction. Investigation of the kallikrein-kinin system in human and experimental forms of hypertension has been minimal. As a part of the investigation of the kallikrein-kinin system in hypertensive disease, an attempt was made to measure the amount of kallikrein in the cortex of the kidney in spontaneously hypertensive, renal hypertensive, and normotensive Sprague-Dawley rats. A bioassay method was used to determine the various levels of bradykinin. The data compiled was compared to similar studies measuring urinary kallikrein.
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