Possible Potentiation of an Antitumor Agent by the Polyene Antibiotics
The hematologic neoplasms, which comprise the acute and chronic leukemias, myelomas and lymphomas, are responsible for 10% of all cancer deaths in adults and 50% of the cancer deaths in children. Combination chemotherapy, which utilizes the combined action of two or more drugs, is one method of effectively controlling. these malignancies. In this study, polyene antibiotics were combined with BCNU (an antineoplastic agent) to enhance the cytocidal activity of the latter.