Comparative Pathogenetic Characteristics of Atherosclerosis
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Authors
Blowers, Constance Lynn
Issue Date
1974
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
A study of the affinities for cholesterol from serum
lipoproteins by elastin and collagen components of the
arterial wall was undertaken. The low-density lipoproteins
(LDL) of human serum and very low-density lipoproteins
(VLDL) of rabbit serum were incubated with bovine tendon
collagen and with porcine aortic elastin. Cholesterol
analysis of the elastin residues revealed a significant
ability of the elastin to bind the lipoprotein cholesterol.
Succinylation of the LDL did not seem to inhibit the amount
of cholesterol transfer. The collagen also bound cholesterol
but to a lesser extent.
A concurrent project of tissue culturing aortas from
various animals with primary interest in growth rate was
done. A strain of Japanese quail resistant to experimental
atherosclerosis (REA) showed significantly less proliferation
of cells as compared with a strain susceptible to experimental
atherosclerosis (SEA) grown under identical conditions
which may suggest something about the genetic predispositions
to atherosclerosis.
Description
v, 36 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.