Comparative Pathogenetic Characteristics of Atherosclerosis
Blowers, Constance Lynn
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A study of the affinities for cholesterol from serum lipoproteins by elastin and collagen components of the arterial wall was undertaken. The low-density lipoproteins (LDL) of human serum and very low-density lipoproteins (VLDL) of rabbit serum were incubated with bovine tendon collagen and with porcine aortic elastin. Cholesterol analysis of the elastin residues revealed a significant ability of the elastin to bind the lipoprotein cholesterol. Succinylation of the LDL did not seem to inhibit the amount of cholesterol transfer. The collagen also bound cholesterol but to a lesser extent. A concurrent project of tissue culturing aortas from various animals with primary interest in growth rate was done. A strain of Japanese quail resistant to experimental atherosclerosis (REA) showed significantly less proliferation of cells as compared with a strain susceptible to experimental atherosclerosis (SEA) grown under identical conditions which may suggest something about the genetic predispositions to atherosclerosis.