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Academic Departments, Programs, and SIPs: Recent submissions
Now showing items 1-20 of 11031
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Magnetic Nanoparticle Imaging and Hyperthermia : On the Binding and Localization of Nanoparticles Using Combination Magnetic Field
(Kalamazoo College, 2008)Different magnetite (Fe3O4) nanoparticles were synthesized and characterized in order to determine their usefulness in future imaging systems and biomedical applications. Characterization was done by vibrating sample ... -
An Improved Synthesis of Petromyzonamine Disulfate
(Kalamazoo College, 2006)Sea lampreys (petromyzon marinus) are a parasitic, invasive species threatening large fish in the great lakes. Traditionally, their population has been controlled by use of the lampricide 4-nitro-3-(trifluoromethyl) phenol ... -
Amino Acid Transport Systems A and N as Targets for Synthetic Drug Design in the Treatment of Neurodegenerative Disorders
(Kalamazoo College, 2008)L-glutamine, is the most abundant amino acid in the body. In the glutamatergic cycle, this amino acid is converted to and from the important neurotransmitter glutamate, which can be harmful when present in large amounts. ... -
Laser-Induced Fluorescence Detection of ATP, cAMP, and GlcN6P by way of Capillary Electrophoresis Using Aptazymes and their Cleavage Products
(Kalamazoo College, 2008)The detection of ATP, cAMP, GlcN6P, and other small biomolecules are of Interest due to their prevalence in a variety of cellular and biological processes. ATP is a carrier of chemical energy, cyclic AMP is a second messenger ... -
Exploration of a Method for the Preparation of 1,10-phenanthroline Derived Chemosensors
(Kalamazoo College, 2008)The exploration of a suitable method for the formation of 5-hydroxy-6-(2- aminopyridine)-1,10-phenanthroline is detailed in the following report. The hope was that 5-hydroxy-6-(2-aminopyridine)-1,10-phenanthroline would ... -
Synthesis of High Value 4-hydroxy and 4-oxo Pipecolic Acid Derivatives from a Process Byproduct
(Kalamazoo College, 2009)Functional transformations of4-substituted pipecolic acid derivatives are described. Many 4-substituted pipecolic acid derivatives are found throughout nature and within many pharmaceutical targets. The goal of this research ... -
Sialylation of Serum Glycoproteins : The role of ST6Gal I sialyltransferase
(Kalamazoo College, 2008)The sialyltransferase ST6Gal-l, mediating the synthesis of the a2,6-sialyl linkage to Gal(pl,4)GlcNAc, is expressed ubiquitously in mammals but with particular abundance in the liver. During the acute phase response - the ... -
Effects of Phase Separation on Charge Mobility in Active Layer of Polymer Solar Cells
(Kalamazoo College, 2008)One of the limiting factors in polymer solar cell performance is charge carrier mobility through the cell. Recently, it has been reported that the hole mobility in certain blends can be enhanced by additional electron ... -
Solid Phase Heck Reaction Catalysis : An Exploration of Reaction Component Modification
(Kalamazoo College, 2008)Described within this report is a detailed analysis and investigation of the Heck reaction using solid phase heterogeneous catalysts. Usinga diol spacer and a phenanthroline ligand, transition metal compounds could be ... -
Synthesis of Metallic Nanoparticles And Their Use in the Photolysis of Water in Conjuction with TiCO2
(Kalamazoo College, 2008)Copper nanoparticles were synthesized using«-dodecyl sulfide to reduce copper (II) acetate in a 50/50 v/v BuOH/ diphenyl ether solvent at high temperatures (-200 °C). The resulting particles were characterized using UV-Vis ... -
Within This Reality: A Novella
(2017) -
HPLC Determination of Terfenadine Metabolism by P450 Enzymes : An Assay for P450 4F12 Enzyme Activity and Organic Solvent Effects
(Kalamazoo College, 2007)Cytochrome P450 enzymes are heme-containing oxidoreductases involved in the metabolism of both endogenous and exogenous compounds in the human body. One class of exogenous compounds known to be metabolized by P450s is ... -
Inducing Cell Death In MCF-7 Cells With Hsp-70 Inhibitors And Geldanamycin
(Kalamazoo College, 2008)Heat shock proteins (HSPs) are a class of chaperones that assist other proteins in assuming their proper three-dimensional shape and, therefore, function. Currently, a lot of research is being directed toward Hsp90 and the ... -
Analysis of the Microenvironments of Immobilized Catalysts using the Heck Reaction
(Kalamazoo College, 2008)A synthesis scheme detailing immobilization of l,10-phenanthroline-5,6-dioneonto a Wang resin solid phase support was developed to create a library of heterogeneous catalysts. The synthesized catalysts differ only in their ... -
An Investigation of the Neuronal NOS and Calmodulin Interactions Following Cross-linking and Proteolysis Using MALDI-MS
(Kalamazoo College, 2006)As a result of the varied physiological and pathological involvement of -NO, regulation of Nitric oxide synthase (NOS) has been at the forefront of many investigations. The three isoforms of this enzyme belong to a group ...
