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Determination of Telomeric Protein Interaction Binding Sites Between Amino Acids 58-268 of TRF1 and 224-276 of TIN2 and Between Amino Acids 42-245 of TRF2 and 203-361 of TIN2
(Kalamazoo College, 2006-04-28)
Telomerase: • A ribonucleoprotein complex, with RNA and protein components, in all eukaryotes • Required for lengthening the ends of telomeric DNA by reverse transcriptase Without Telomerase: • Unable to lengthen ...
Determination of telomeric protein interaction binding sites between amino acids 58-268 of TRF1 and 224-276 of TIN2 and between amino acids 42-245 of TRF2 and 203-361 of TIN2
(Kalamazoo College, 2006)
Interactions of telomeric protein-protein complexes have important implications in the development of diseases such as cancer. Approximately 90% of all cancer cases are associated with the reactivation of telomerase ...