Synthesis and Spectroscopic Characterization of Copper (I) and Copper (II) Nitrosyl Complexes with Tris(2-pyridylmethyl)amine Ligand
Abstract
Copper nitrite reductase (CuNIR) is a metalloprotein found in bacteria that reduces nitrite
to nitric oxide (NO). The binding mode of NO to CuNIR has high significance for the
understanding of the catalytic mechanism of CuNIR and in particular, the role of the
amino acids that are located within the active site. An X-ray crystal structure of NO
bound to copper in CuNIR was found to be side-on while all model complexes of Cu-NO
have been reported to have end-on geometries. The coordination chemistry of NO with
cooper(I) and copper (II) complexes were investigated with the tetradentate ligand tris(2-
pyridylmethyl)amine (TPA). The complex [CuI(TPA)(CH3CN)]PF6 was synthesized
followed by the reactions with NO and NOBF4 in attempt to produce [CuI(TPA)(NO)]+
and [CuII(TPA)(NO)]2+. The progression of the reactions were monitored via dip-probe
UV-Vis spectroscopy, which showed the formation of Cu(II) complexes with NO
reaction; the spectra of the NOBF4 reaction indicated the nitrosylation of the amine
backbone prior interacting with the copper center . The EPR spectra also showed the
formation of Cu(II) complexes with the NO reaction and a mixture of Cu(II) complexes
with the NOBF4 reaction. The results provided valuable insights to the understanding of
the NO species with Cu-TPA complex.
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