Electrophoretic Studies of the Median Eminence
Freytag, David Paul
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Two hypotheses have been proposed upon which work could be done. First, neurosecretory material (NSM) might have been composed of the various hormones that were eventually secreted by the hypopbysis. In this case, it would have been the function of the various cells (alpha, beta, delta) of the hypophysis to have reacted, differentially removing the appropriate portions of the neurosecretory material as their secretions. The regulatory role played by the hormones reaching the hypothalamus would have then been to bind with the neurosecretory material at various points and to have behaved as an inhibitor to the function of the hypopbyseal cells. Second, different cellular groups of the hypothalamus might have produced individual release factors as components of the NSM which, upon reaching appropriate cells in the hypophysis stimulated these cells to production of the appropriate bypophyseal hormones. These hormones then, upon reaching the hypothalamus could have attached themselves to individual components of the NSM, caused factors to become attached to these components, or directly inhibited the synthesis and/or secretion of the release factor. This would have led to a decrease in the output of the hypophyseal hormones.