Show simple item record

dc.contributor.advisorAnderson, Bradley D.
dc.contributor.authorInnes, Jennifer B.
dc.date.accessioned2010-09-22T14:50:25Z
dc.date.available2010-09-22T14:50:25Z
dc.date.issued1983
dc.identifier.urihttp://hdl.handle.net/10920/17369
dc.descriptioniii, 40 p.en_US
dc.description.abstractWith the goal of rapid regeneration independent of enzyme action in mind, this project will examine the kinetics and mechanisms of the hydrolysis of certain carboxylic acid esters. Ester linkages are common in prodrugs, and hydrolysis of the link releases the parent drug from the pro-moiety. Ester hydrolysis does not normally occur rapidly, particularly when there is a great deal of steric hindrance around the ester linkage, but the citrate ester of flurbiprofen, expected to be quite stable due to steric hirndrance by three carboxyl groups, has been found to hydrolyze readily at certain pH's. The proposed mechanism involves an intramolecular catalysis by the carboxyl groups of the citrate. While flurbiprofen citrate has not proven viable for drug use, its mechanism of hydrolysis is interesting in that it suggests that intramolecular catalysis may offer a way to control drug release by non-enzymatic means.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleIntramolecular Catalysis of the Hydrolysis of Polycarboxylic Acid Prodrugsen_US
dc.typeThesisen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

  • Chemistry Senior Individualized Projects [820]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

Show simple item record