Analogs of Tirandamycin
Loading...
Authors
Elrod, David W.
Issue Date
1974
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The purpose of this SIP was to chemically modify the antibiotic
tirandamycin in order to increase either its spectrum of activity or
its potency. The cyc1ohexy1 amide of tirandamycic acid was prepared.
Based on the work done by Mager1ein, tirandamycy1 chloride was condensed
with various 1,3-dicarbony1 compounds. In addition, condensation was
tried with other activated methylene compounds such as ethyl cyanoacetate,
ma1ononitri1e and dimethyl methy1phosphonate.
Description
iv, 65 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.