Analogs of Tirandamycin

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Authors
Elrod, David W.
Issue Date
1974
Type
Thesis
Language
en_US
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Abstract
The purpose of this SIP was to chemically modify the antibiotic tirandamycin in order to increase either its spectrum of activity or its potency. The cyc1ohexy1 amide of tirandamycic acid was prepared. Based on the work done by Mager1ein, tirandamycy1 chloride was condensed with various 1,3-dicarbony1 compounds. In addition, condensation was tried with other activated methylene compounds such as ethyl cyanoacetate, ma1ononitri1e and dimethyl methy1phosphonate.
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iv, 65 p.
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Kalamazoo College
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U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
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