The Degradation of Methyl Prednisolone 21-Hemisuccinate and the Synthesis of Methyl Prednisolone 21-Hemiesters
Taphouse, Vanessa M.
MetadataShow full item record
A quantitative, mechanistic understanding of the degradation pathways of methyl prednisolone 21-hemisuccinate is essential to the design of other soluble prodrugs of methyl prednisolone with improved aqueous stability. The first objective of this study was to determine the effect of pH on the hydrolysis rate over a wide pH range. The ester was found, to undergo rearrangement to the 17-hemisuccinate ester III, in addition to hydrolysis to the alcohol. Rate constatns for the formation of these two products, as well as for the formation of the 21-ester from the 17-ester have been determined over the range pH 2-9.
Showing items related by title, author, creator and subject.
Pedroso, Farah L. (Kalamazoo College, 2007-04-27)The Solanaceae family produces an array of volatiles, which are thought of having a direct effect on the environment by attracting pollinators, providing herbivory defense and performing antimicrobial functions. Nicotiana ...
Gaussian 98w Modeling of No2 and Methyl Tritate and its Application towards the Second Energy State Photodissociation of cis-methyl Nitrite Richards, Benjamin T. (Kalamazoo College, 2013)Methyl nitrite (CH3ONO) is a bent, polyatomic molecule this is used frequently in photodissociation chemistry due to the relative stability of the cis-isomer at room temperature. In photodissociation chemistry, the ...
Pedroso, Farah L. (Kalamazoo College, 2007)Many plants like those of the Solanaceae family produce an array of volatiles, airborne chemicals emitted from planta tissue, through a methylating pathway. In which methyl group is donated and transferred from ...