The Distribution and Partial Characterization of Inactive Clindamycin Matabolites in the Rat
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Authors
Walters, Valerie A.
Issue Date
1978
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The purpose of the present study is to detect and determine the
distribution of the inactive clindamycin metabolites in rats present
at 0.5 hours after oral administration of clindamycin. In addition,
the separation and characterization of these compounds are to be
attempted. The method used to detect these compounds and determine
their distribution involves the use of radioactive clindamycin. The
clindamycin compounds, active and inactive, found in a particular
tissue are detected using a radioactivity assay. The antibacterially
active compounds are differentiated from the inactive compounds using
bioautographic techniques. A supplementary method is attempted which
involves a gas chromatographic analysis of trimethylsilylated derivatives
of organ homogenates.
Description
iii, 68 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.