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dc.contributor.advisorBrodasky, Thomas F.
dc.contributor.authorWalters, Valerie A.
dc.descriptioniii, 68 p.en_US
dc.description.abstractThe purpose of the present study is to detect and determine the distribution of the inactive clindamycin metabolites in rats present at 0.5 hours after oral administration of clindamycin. In addition, the separation and characterization of these compounds are to be attempted. The method used to detect these compounds and determine their distribution involves the use of radioactive clindamycin. The clindamycin compounds, active and inactive, found in a particular tissue are detected using a radioactivity assay. The antibacterially active compounds are differentiated from the inactive compounds using bioautographic techniques. A supplementary method is attempted which involves a gas chromatographic analysis of trimethylsilylated derivatives of organ homogenates.en_US
dc.description.sponsorshipUpjohn Company, Kalamazoo, Michigan
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Chemistry Senior Individualized Projects Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleThe Distribution and Partial Characterization of Inactive Clindamycin Matabolites in the Raten_US

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  • Chemistry Senior Individualized Projects [889]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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