The Effect of Dietary Di-2-Ethyl Hexyl Phthalate on Rate Platelet Lipid Synthesis
Di-2-ethylhexyl phthalate (DEHP) is a compound used to "flexibilize" polyvinylchloride plastics. However, DEHP is not bonded to the plastic matrix and therefore can migrate into its environment. The most alarming example of migration is the presence of DEHP in medical blood storage bags. Over one million pounds of DEHP is produced yearly and as a result of the common use and method of disposal of plastic products, DEHP has become an environmental contaminant at concentration levels in the ocean higher than DDT. Since preliminary research on the effect of DEHP on biological systems has shown an alteration of lipid metabolism in various cells, the purpose of my project was to examine the effects of dietary DEHP on rat platelet lipid synthesis.