Photon Correlation Studies of the Self-Associative Properties of Methylprednisolone 21-Hemisuccinate
Ransdell, Robert A.
MetadataShow full item record
The apparent size of micelles formed in solutions of sod1um methylprednisolone hemisuccinate have been studied as a function of concentration (20-100 mg/ml). added KCl, and time. The apparent hydrodynamic diameters were found to depend on ionic strength and ranged from 25 to 50 A. increasing with ionic strength. Diameters increased with time until the formation of precipatate. This occurred within a few hours at low ionic strength and concentration. Increasing the ionic strength or concentration suppressed precipitation. 100 mg/ml, 1M KCl solutions did not show precipitate at 220 hours.