The Role of Aspartate in Retarding Fatigue in the Neuromuscular Level

Abstract

The purpose of this investigation was to study the effect of aspartate in retarding fatigue at the neuro-muscular level. Various studies have been reported in which aspartate has been administered. Laborit, et. al. found that the K salt of aspartate reduced fatigue at this level. They postulated that "aspartic acid which functions in an intermediate position in the Krebs cycle should provide a suitable substrate for the increase of metabolic efficiency or delay of metabolic exhaustion." Aspartate was administered orally to rats. They were then put in a vat to swim until fatigue set in.

With honors.