The Effects of Thyoidectomy on the Pancreatic Amylase, RNA, and DNA in Rats
Kammerer, Agnes Ruth
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Thyroidectomy of Rattus has been studied by researchers for many years. The operation results in a general decline in the metabolic activity by the rat. The relationship between the thyroid and the pancreas has been noted. The reduction in size of the pancreas caused by thyroidectomy and the decrease in amylolytic activity is substantiated. The question remaining was the mechanism by which the thyroid controlled the amylolytic activity of the pancreas. This was the purpose of this research. It was proposed that thyroxin acts directly on the pancreatic DNA, which then produces RNA which in turn produces amylase. By eliminating the thyroid gland, the resulting activity of the pancreas could be recorded by measuring the DNA, RNA, end amylase content of the pancreas. If the RNA and amylase showed a decrease while the DNA remained constant then the results would be in concord with the hypothesis.