The Effect of Circulating Antibody on Cutaneous Herpes Infection in Hairless Mice
Underwood, Gary E.
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The role of antibodies in inhibition of virus infections has been examined by many people. This search has extended to herpes virus in mice. Peak antibody strengths in response to subcutaneous injections of live herpes virus in haired white mice was studied by Sydiskes and Schultz. In an earlier series of tests Sydiskis and Schultz had examined the development of cutaneous lesions in white mice in response to subcutaneous infections of varying strengths of herpes virus solutions. We felt there was value in a study of the effect of this observed antibody production on a subsequent cutaneous viral challenge. Underwood has recently instigated research with cutaneous herpes infections in hairless mice. Lesion progress was more easily observed. It was free from the considerations of trauma during hair removal and hair regrowth which complicated the results of Sydiskis and Schultz. Provided with an animal suitable for observation, it was possible to examine the effect of antibodies on the cutaneous herpes infection. Two methods of introduction of antibodies into the mouse were examined: inoculation with herpes immune serum and inoculation with a sub-lethal dose of live herpes virus to stimulate antibody production. The mice were then challenged cutaneously. This paper reports the effects of these different sources of circulating antibody on the growth of the cutaneous herpes lesion.If you are not a current K College student, faculty, or staff member, email email@example.com to request access to this SIP.