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dc.contributor.authorBandy, David B.
dc.description1 broadsideen_US
dc.description.abstractHox genes play a major role in the development of animal body plans. They are highly conserved amongst the animal taxa, and are hypothesized to be the cause of the Cambrian Explosion 530 million years ago. Mutations in various Hox genes can lead to dramatic structural malformation and malfunction in animals. The Hox6 paralogous group is of particular interest because simultaneous mutations in all 3 Hox6 clusters leads to premature death shortly after birth in mice (Mus musculus). Based on the anterior to posterior patterning of the mammalian Hox genes (Figure 1), and the suspected location of Hox6 gene expression, it was hypothesized that Hox6 triple mutant mice died because of a misshapen or malformed diaphragm. Such a deficiency would prevent the newborn mice from inhaling, and death would occur via hypoxia. The purpose of this experiment was to determine if a poorly developed diaphragm was the cause of death of Hox6 triple mutant mice.en_US
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2010en_US
dc.publisherKalamazoo, Mich. : Kalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Diebold Symposium Presentation Collectionen
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.en
dc.titleMutations in the Hox6 Paralogous Group do not Affect Diaphragm Development in Miceen_US

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  • Diebold Symposium Posters and Schedules [479]
    Poster and oral presentations by senior biology majors that include the results of their Senior Integrated Projects (SIPs) at the Diebold Symposium. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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